Blog

Updates on Temple Compute OS and horus-runtime.

October 5, 2026

Airflow vs Nextflow: Which Fits Scientific Pipelines?

Airflow schedules data pipelines in Python. Nextflow runs scientific pipelines on HPC in a Groovy DSL. Where each fits, where each breaks, and how to choose.

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October 5, 2026

Cryptic Pocket Detection: Find Hidden Binding Sites

Why geometric pocket finders miss cryptic binding sites, how ensemble-based detection with Lacuna finds them, and how to run it on any compute.

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October 5, 2026

Docking into Cryptic Pockets with Lacuna and AutoDock Vina

Cryptic pockets are closed in the apo structure, so docking misses them. Find and rank them with Lacuna, then dock a ligand library with AutoDock Vina.

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October 5, 2026

fpocket Cavity Analysis for Cavity-Guided Virtual Screening

Detect and rank binding pockets with fpocket across a conformational ensemble, then dock a ligand library into the best cavity. Two open workflows.

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October 5, 2026

Generative Ligand Design with DrugFlow and Boltz-2

Generate ligands in a pocket with DrugFlow, score each with Boltz-2 affinity, and rank by ΔG. One workflow, GPU stages routed to the hardware you pick.

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October 5, 2026

How to Automate Parametric Studies on HPC and Cloud

A parametric study is a fan-out, a gather, and sometimes a loop. How to orchestrate sweeps and optimization runs across CPU, GPU, HPC and cloud without glue code.

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October 5, 2026

Train an LLM From Scratch: A Pretrain, SFT, Eval Pipeline

Train an LLM from scratch as a DAG: CPU stages tokenize, GPU stages pretrain and fine-tune, eval scores GSM8K. Start on TinyStories, then scale up.

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August 5, 2026

We put our workflow engine in charge of our codebase

tc-agent-loop is an autonomous issue-to-PR agent built entirely on horus-runtime. Open an issue, comment /missues, and our own workflow engine plans, implements, validates, and opens a pull request.

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August 2, 2026

Best HPC Workflow Orchestration Tools for Simulation (2026)

11 HPC and cloud orchestration tools compared for simulation and science pipelines: Nextflow, Snakemake, Airflow, Modal, Flyte and Temple Compute OS.

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July 22, 2026

+25 production workflows for heterogeneous compute

We open-sourced pantheon: +25 ready-to-run molecular dynamics, docking, and virtual screening workflows where every stage picks its own compute target.

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July 15, 2026

Why We Built the horus-runtime

Years working at a supercomputing center taught me one thing: almost nobody enjoys configuring HPC environments.

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July 11, 2026

horus-runtime is open source

horus-runtime, the workflow execution engine underneath Temple Compute OS, is open source and ungated. Here's what it does and where to find it.

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July 11, 2026

Introducing Temple Compute OS

Run research workflows on HPC and every major cloud without touching a scheduler config. The managed platform built on the open-source Horus engine.

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